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Rifaxerose

GIT
Product

Rifaxerose

Active

(Rifaximin 550 mg) Film coated tablets

Category
GIT
Indication

Rifaxerose is indicated for the reduction in recurrence of episodes of overt hepatic encephalopathy in patients ≥ 18 years of age . used as primary prophylaxis of hepatic encephalopathy

In the pivotal study, 91% of the patients were using concomitant lactulose.

Consideration should be given to official guidance on the appropriate use of antibacterial agents.

Used in traveler’s Diarrhea .

Dose

Recommended dose: 550 mg twice a day. The clinical benefit was established from a controlled study in which subjects were treated for 6 months. Treatment beyond 6 months should take into consideration the individual balance between benefits and risks, including those associated with the progression of hepatic dysfunction .

Rifaxerose can be administered with or without food.

Paediatric population

The safety and efficacy of Rifaxerose in paediatric patients (aged less than 18 years) have not been established.

Elderly

No dosage adjustment is necessary as the safety and efficacy data of Rifaxerose showed no differences between the elderly and the younger patients.

Hepatic impairment

No dosage adjustment is necessary for patients with hepatic insufficiency .

Renal impairment

Although dosing change is not anticipated, caution should be used in patients with impaired renal function .

Method of administration

Orally with a glass of water.